Poor prognosis colon cancer is defined by a distinct molecular subtype and develops from serrated precursor lesions

Authors De Sousa E Mello, F†, Wang X†, Jansen M, Fessler E, Trinh A, et al Nature Medicine 2013, doi:10.1038/nm.3174. Abstract Colon cancer is a clinically diverse disease. This heterogeneity makes it difficult to determine which patients will benefit most from adjuvant therapy and impedes the development of new targeted agents. More insight into the biological diversity of colon cancers, especially in relation to clinical features, is therefore needed. We demonstrate, using an unsupervised classification strategy involving over 1,100 individuals with colon cancer, that three main molecularly distinct subtypes can be recognized.

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