Regeneration of cortical tissue from brain injury by implantation of defined molecular gradient of semaphorin 3A.
Authors Zhen Xua, Wang W, Yutian Ren, Wenchong Zhang, Peilin Fang, Linfeng Huang, XinWang, Peng Shi. Biomaterials 2018 Abstract Despite great efforts in the exploration of therapeutic strategies for treating brain injuries, it is still challenging to regenerate neural tissues and to restore the lost function within an injured brain. In this report, we employed a tissue engineering approach to regenerate cortical tissue from brain injury by implantation of defined semaphorin 3A (Sema3A) gradient packaged in a hydrogel based device.