mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.
Authors He L, Gomes AP†, Wang X†, Yoon SO, Lee G, Nagiec M, Cho S, Chavez A, Islam T, Yu Y, Asara JM, Kim BY, Blenis J. Molecular Cell 2018, doi:https://doi.org/10.1016/j.molcel.2018.04.024 Abstract Highlights mTORC1 suppresses GSK3-dependent Foxk1 phosphorylation Foxk1 phosphorylation promotes 14-3-3 binding and nuclear exclusion Foxk1 transcriptionally regulates Hif1α expression Foxk1 and Hif1α contribute to mTORC1-regulated metabolic reprogramming Summary The mammalian Target of Rapamycin Complex 1 (mTORC1)-signaling system plays a critical role in the maintenance of cellular homeostasis by sensing and integrating multiple extracellular and intracellular cues.