Semin Cancer Biol

Molecular subtyping of colorectal cancer: recent progress, new challenges and emerging opportunities.

Authors Wang W†, Kandimalla R†, Huang H†, Zhu L, Li Y, Gao F, Goel A*,Wang X* Seminars in Cancer Biology 2018, doi:10.1016/j.semcancer.2018.05.002 Abstract Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Similar to many other malignancies, CRC is a heterogeneous disease, making it a clinical challenge for optimization of treatment modalities in reducing the morbidity and mortality associated with this disease. A more precise understanding of the biological properties that distinguish patients with colorectal tumors, especially in terms of their clinical features, is a key requirement towards a more robust, targeted-drug design, and implementation of individualized therapies.

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